Reliable identification and characterization of proteins and peptides are very important tasks for biomedical research. We provide end-to-end MS-based proteomic services to unravel the complexity of biological systems. Whether you want to identify a protein, quantify protein expression, discover new biomarkers or characterize therapeutic antibodies, let us be your partner in innovation.

The goal of our services is to make our cutting-edge technology accessible to wider biopharmaceutical community. Aided by state-of-the-art equipment and staffed with highly trained scientists, PTM Biolabs has been continuously delivering the highest quality data to clients worldwide from industry, academia, and government organizations.

  • Advanced technology featuring industry’s highest throughput: up to 10,000 proteins quantified in one single experiment;
  • Solid science foundation demonstrated by continuous history of publications in renowned peer reviewed journals.

Satisfied customers are essential to our success. We achieve total customer satisfaction by listening to your specific needs, addressing the issues with our expertise and finally delivering the results toward your success. We practice the highest ethical standards, and honor our commitments. We take profound responsibility for each and every step of our actions, and treat everyone fairly with trust and respect.
Don’t know what to do with the giant MS datasets!! PTM’s bioinformatics team assists clients in analyzing their large amounts of MS data in a variety of fields – including

  • Gene Ontology analysis: cell component, molecular function and biological process;

GO

  • Cytoscape STRING: protein-protein interaction analysis;

STRING_network_image

  • INTERPO: for domain analysis;

Motif

  • KEGG: metabolic pathway analysis.

Kegg

PROTEIN

IDENTIFICATION

We provide the best protein ID solution with our high-sensitivity mass spectrometry technology. We help identify a purified protein, proteins in a complex mixture, interacting proteins, and differences between 2 (or more) complex protein mixtures, as well as determine molecular mass for peptides or proteins.

Proteins are digested with trypsin and the resulting peptides are analyzed by LC-MS/MS. The peptides are fragmented in a mass spectrometer to yield diagnostic MS/MS patterns that can be matched to protein sequence databases via computer algorithms. The sensitivity of this technique is about 0.05ng for a gel sample. Customer-specific methods can be established, developed or advanced by request.

Samples from 2DE gel spots, 1DE gel bands, and protein mixture in solution are accepted. We request >0.01 pmol starting materials or visible gel bands using any staining method.
Our Ph.D. trained scientists strive to provide the best support to each and every one of our customers. Free consultation is just one click away!

QUANTITATIVE

PROTEOMICS

Quantitative proteomics is a powerful approach to understand global proteomic dynamics in a cell, tissue or organism. We offer quantitative proteomic solutions to meet your diverse needs, utilizing in vivo labeling (SILAC), in vitro labeling (iTRAQ/TMT), and label free technologies. Our high quality datesets help understand the underlying molecular mechanisms behind biological processes, disease states, and drug treatment.

This service involves sample digestion with appropriate enzymes prior to LC-MS/MS analysis. Fractionation will be performed if necessary. The resulting MS/MS data are searched against protein sequence databases. This approach maximizes the sequence coverage observed for your proteins.

We accept tissue samples from animals and plants, bacteria samples, body fluid, cell pellets, and cell lysates.
Our technology is featured with high sensitivity: capable of detecting and quantifying 8,000 – 10,000 proteins in mammalian cells; and high reliability: with expert manual verification available.
Qian et al. (2015). Analyzing Arabidopsis thaliana root proteome provides insights into the molecular bases of enantioselective imazethapyr toxicity. Scientific reports 5, 11975. PMID: 26153126.

Zhu et al. (2016). Quantitative Analysis of Global Proteome and Lysine Acetylome Reveal the Differential Impacts of VPA and SAHA on HL60 Cells. Scientific reports 6, 19926. PMID: 26822725

Wang, Z. K., J. Wang, et al. (2016). “Proteomic and Phosphoproteomic Insights into a Signaling Hub Role for Cdc14 in Asexual Development and Multiple Stress Responses in Beauveria bassiana.” PLoS One 11(4): e0153007. PMID: 27055109

Our Ph.D. trained scientists strive to provide the best support to each and every one of our customers. Free consultation is just one click away!

WHOLE PROTEOME

ANALYSIS

Proteomes are highly complex and identifying low abundance proteins could be a challenging issue. We provide MS-based proteomic services to characterize proteins at the whole proteome level. It produces high-quality datasets with extended bioinformatic analysis to aid your quest for novel insights into biological functions. Customized analyses are available to investigate particular proteome fractions of your interests, such as nuclear proteins, histone proteins, mitochondrial proteins, membrane proteins, and more…

This service involves sample digestion with appropriate enzymes prior to LC-MS/MS analysis. Fractionation will be performed if necessary. The resulting MS/MS data are searched against protein sequence databases. Our approach maximizes the sequence coverage observed for your proteins.

We accept tissue samples from animals and plants, bacteria samples, body fluid, cell pellets, and cell lysates.
Our technology features with high sensitivity: capable of detecting and quantifying 8,000 – 10,000 proteins in mammalian cells; and high reliability: with expert manual verification available.
Our Ph.D. trained scientists strive to provide the best support to each and every one of our customers. Free consultation is just one click away!